Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-07-18
2006-07-18
Kerr, Kathleen (Department: 1652)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000, C530S350000, C435S069200, C435S069700, C514S002600
Reexamination Certificate
active
07078383
ABSTRACT:
Mutants of Kunitz domain 1 (ITI-D1) of human inter-α-trypsin inhibitor (ITI), are useful as inhibitors of human neutrophil elastase. Mutants characterized by one or more of the following substitutions (numbered to correspond to bovine pancreatic trypsin inhibitor, the archetypal Kunitz domain) are of particular interest: (a) Val15 or Ile15, (b) Ala16, (c) Phe18, (d) Pro19, (e) Arg1, (f) Pro2, and/or (g) Phe4.
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Guterman Sonia K
Kent Rachel B
Ladner Robert C
Ley Arthur C
Markland William
Dyax Corp.
Kerr Kathleen
Moore William W.
Wolf Greenfield & Sacks P.C.
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