Isoxazolyl and isothiazolyl aromatase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514378, 546275, 546280, 548206, 548214, 548247, A61K 3142, A61K 31425, C07D26108, C07D27502

Patent

active

045606951

ABSTRACT:
This invention provides certain isoxazole and isothiazole derivatives, their pharmaceutical formulations, and their use in inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.

REFERENCES:
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patent: 3794653 (1974-02-01), Draber et al.
patent: 3852056 (1974-12-01), Draber et al.
patent: 3897438 (1975-07-01), Draber et al.
Ashton, et al., "Heterocyclic Analogs of Chlorcyclazme", Chem. Abst. 101:130647(f) (1984).
Vita-Finzi, et al., "Reaction of Benzonitrile Oxides . . . ", Chem. Abst. 62:14646(d) (1965).

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