Isoxazolopyridone derivatives and their use

Details Isoxazolopyridone derivatives and their use Isoxazolopyridone derivatives and their use

2006-05-30

2006-05-30

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S115000, C514S302000

Reexamination Certificate

active

07053219

ABSTRACT:
The invention relates to isoxazolopyridone derivatives of a formula (I-a):wherein R1arepresents an optionally-substituted heteroaryl or phenyl group, R2arepresents an optionally-substituted phenyl or heteroaryl group, and R3arepresents a methyl group, provided that, (1) when R1ais an unsubstituted phenyl group, then R2amust not be a para-substituted phenyl group of which the substituent is any of a methoxy group, a chloro group, a methyl group, a trifluoromethyl group, a fluoro group, a bromomethyl group or a dimethylaminomethyl group, and R2amust not be an unsubstituted heteroaryl group, and (2) when R1ais a 4-tolyl group or a 4-fluorophenyl group, then R2amust not be an unsubstituted phenyl group, a 4-methoxyphenyl group or a 4-fluorophenyl group, or their pharmaceutically-acceptable salts.The isoxazolopyridone derivatives or their pharmaceutically-acceptable salts of the invention have a metabotropic glutamic acid receptor-antagonistic effect, and are useful for remedy of, for example, anxiety disorders, psychosomatic disorders, obsessive-compulsive neurosis, bipolar disorders, melancholia, eating disorders, schizophrenia, multi-infarct dementia, Alzheimer disease, epilepsy, Parkinson disease, Huntington's chorea, pain or retrograde neurosis.

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