Isoxazolo-pyrazine derivatives

Details Isoxazolo-pyrazine derivatives Isoxazolo-pyrazine derivatives

2008-11-25

2009-11-17

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S336000, C544S353000, C548S240000

Reexamination Certificate

active

07618973

ABSTRACT:
The invention relates to isoxazolo-pyrazine derivatives and their pharmaceutically acceptable salts having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, and pharmaceutical compositions containing them. The compounds of present invention are inverse agonists of GABA A α5. The invention also relates to methods for enhancing cognition and for treating cognitive disorders like Alzheimer's disease.

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