Isoxazolo-pyrazine derivatives

Details Isoxazolo-pyrazine derivatives Isoxazolo-pyrazine derivatives

2011-03-08

2011-03-08

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S405000, C548S247000

Reexamination Certificate

active

07902201

ABSTRACT:
The invention relates to isoxazolo-pyrazine derivatives and their pharmaceutically acceptable salts having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, and pharmaceutical compositions containing them. The compounds of the present invention are inverse agonists of GABAAα5. The invention also relates to methods for enhancing cognition and for treating cognitive disorders like Alzheimer's disease.

REFERENCES:
patent: 4639266 (1987-01-01), Heubach et al.
patent: 2003/0055085 (2003-03-01), Wagener et al.
patent: 2004/0006226 (2004-01-01), Ladduwahetty et al.
patent: 3525205 (1986-03-01), None
patent: 2336589 (1999-10-01), None
patent: 2007230909 (2007-09-01), None
patent: 0129015 (2001-04-01), None
patent: 0134603 (2001-05-01), None
patent: 0250062 (2002-06-01), None
patent: 02081474 (2002-10-01), None
patent: 03004027 (2003-01-01), None
patent: 03015771 (2003-02-01), None
patent: 03044017 (2003-05-01), None
patent: 2004048349 (2004-06-01), None
patent: 2005014553 (2005-02-01), None
patent: 2005118568 (2005-12-01), None
patent: 2005123672 (2005-12-01), None
patent: 2006037480 (2006-04-01), None
patent: 2006044617 (2006-04-01), None
patent: 2006069155 (2006-06-01), None
patent: 2007009275 (2007-01-01), None
patent: 2007039389 (2007-04-01), None
patent: 2007052843 (2007-05-01), None
patent: 2007076260 (2007-07-01), None
patent: 2007092751 (2007-08-01), None
patent: 2008025539 (2008-03-01), None
patent: 2008025540 (2008-03-01), None
McNamara et al., Psychobiology (1993), vol. 21, pp. 101-108.
Goodman et al., Tetrahedron (1999) vol. 55 pp. 15067-15070.
Roy et al., Synthesis, 2003 pp. 1347-1356.
White, et al., Journal of Organic Chemistry (1981), vol. 46(11) pp. 2273-2280.
Shi Shun et al., J. Org. Chem. vol. 68 (2003) pp. 6810-6813.
Lam et al., Bioorganic & Medicinal Chemistry Letters (2003) vol. 13(10) pp. 1795-1799.
Wang et al., Journal of Fluorine Chemistry, vol. 111(2) pp. 241-246 (2001).
Hamper et al., J. Agric. Food Chem. (1995), vol. 43, pp. 219-228.
Kumar, et al., Tetrahedron Letters, vol. 47, (2006), p. 1457-1460.
Burke, et al., Journal of Natural Products, 1986, vol. 49, pp. 522-523.
Hormi, Organic Syntheses, vol. 8. p. 247 (1993) & vol. 66, (1988), p. 173.
Andosova et al., Pharmaceutical Chemistry Journal (English Translation), vol. 12, No. 8, 1978, pp. 1019-1022.
Doyle, et al., Journal of the Chem. Society, 1963, pp. 5838-5845.
Anderson, et al., Journal of Organic Chem. vol. 51(6), 1986, pp. 945-947.
Bourbeau et al., Organic Letters, vol. 8(17), 2006, pp. 3670-3680.
Waldo et al., Org. Lett. vol. (7) pp. 5203-5205 (2005).
Seydel et al., J. Med. Chem. vol. (19) pp. 483-492 (1976).
Kirk, K. L., J. Org. Chem. vol. (43) pp. 4381-4383 (1978).
Ley et al., Angew Chem, 2003 vol. 115 p. 5558-5606.
Hüttel et al., Liebigs, Ann. Chem. vol. 593, pp. 200-207 (1955) (English translation).
Austin et al., J. Org. Chem. vol. 46, pp. 2280-2286 (1981).
Schlosser et al., Eur. J. Org. Chem. vol. (24), p. 4181-4184 (2002).
Félix et al., J. Org. Chem. 1995, vol. 60 p. 3907-3909.

Affiliated with

Also associated with

Rating

Isoxazolo-pyrazine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isoxazolo-pyrazine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isoxazolo-pyrazine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2678637