Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S362000

Reexamination Certificate

active

07825123

ABSTRACT:
The present invention provides compounds of formula I, having affinity and selectivity for the dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the therapeutic and/or prophylactic treatment of cognitive disorders.

REFERENCES:
patent: WO 2007/148208 (2007-12-01), None
patent: WO 2009/013212 (2009-01-01), None
Missale et al., Physiol. Rev. vol. 78 pp. 189-225 (1998).
Gurevich E. V., Neuropsychopharmacology vol. 20 pp. 60-80 (1999).
Joyce J. N., Drug Discovery Today 1, vol. 10, No. 13 pp. 917-925 (2005).
Gurevich E.V., Arch. Gen. Psychiatry vol. 54 pp. 225-232 (1997).
Knutsen et al. Biorg. Med. Chem. Lett. vol. 17 (2007) pp. 662-667.

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