Isoxazoline intermediates

Details Isoxazoline intermediates Isoxazoline intermediates

1987-06-25

1988-08-30

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549347, 548240, 548110, C07D21516, C07D32100, C07D26102, C07D23100

Patent

active

047678631

ABSTRACT:
New and more efficient chemical processes are provided for preparing (.alpha.S, 5S)-.alpha.-amino-3-chloro-2-isoxazoline-5-acetic acid (AT-125), (.alpha.S, 5S)-.alpha.-amino-3-bromo-2-isoxazoline-5-acetic acid (bromo AT-125) and the C-5 epimers thereof. The disclosed processes allow the above-mentioned antitumor agents to be produced in high yield and purity with substantially fewer steps than prior art chemical procedures.

REFERENCES:
patent: 4188324 (1980-02-01), Martin

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