Isoxazoline-indole derivatives with an improved...

Details Isoxazoline-indole derivatives with an improved... Isoxazoline-indole derivatives with an improved...

2005-11-25

2009-12-22

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S321000, C514S338000, C546S198000, C546S272100

Reexamination Certificate

active

07635696

ABSTRACT:
The present invention relates to novel isoxazoline-indole derivatives according to Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, with a binding affinity towards dopamine receptors, in particular towards dopamine D2and/or D3receptors, with selective serotonin reuptake inhibition (SSRI) properties and showing an affinity for the 5-HT1Areceptor, pharmaceutical compositions comprising the compounds according to the invention, the use thereof for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic disorders, most in particular schizophrenia and processes for their production, wherein the variables are further defined in the application.

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