Isoxazoline derivatives useful as antimicrobials

Details Isoxazoline derivatives useful as antimicrobials Isoxazoline derivatives useful as antimicrobials

2006-04-04

2006-04-04

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S226800, C514S227800, C514S236200, C514S254020, C514S256000, C514S269000, C544S055000, C544S060000, C544S096000, C544S112000, C544S113000, C544S238000, C544S242000, C544S367000

Reexamination Certificate

active

07022705

ABSTRACT:
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,wherein, for example,HET is an N-linked 5-membered, fully or partially unsaturated heterocyclic ring, orHET is an N-linked 6-membered di-hydro-heteroaryl ring;Q is, for example, Q1 or Q2:wherein R2and R3are independently hydrogen or fluoro;T is selected from a range of groups, for example a group of the formula (TC7)wherein Rc is, for example, hydrogen, R13CO—, R13SO2— or R13CS—;wherein R13is, for example, optionally substituted (1–10C)alkyl or R14C(O)O(1–6C)alkylwherein R14is optionally substituted (1–10C)alkyl; are useful as antibacterial agents; andprocesses for their manufacture and pharmaceutical compositions containing them are described.

REFERENCES:
patent: 3318878 (1967-05-01), Dunn
patent: 3769295 (1973-10-01), Hoyle
patent: 5156669 (1992-10-01), Zierke et al.
patent: 199 09 785 (2000-09-01), None
patent: 199 62 924 (2001-07-01), None
patent: 0 455 052 (1991-11-01), None
patent: 1 227 084 (2002-07-01), None
patent: WO-93/23384 (1993-11-01), None
patent: WO-97/14690 (1997-04-01), None
patent: WO-97/23212 (1997-07-01), None
patent: WO-97/27188 (1997-07-01), None
patent: WO-97/30995 (1997-08-01), None
patent: WO-97/31917 (1997-09-01), None
patent: WO-97/43280 (1997-11-01), None
patent: WO-98/01446 (1998-01-01), None
patent: WO-98/01447 (1998-01-01), None
patent: WO-98/07708 (1998-02-01), None
patent: WO-98/15541 (1998-04-01), None
patent: WO-98/57937 (1998-12-01), None
patent: WO-99/10343 (1999-03-01), None
patent: WO-99/11642 (1999-03-01), None
patent: WO-99/10342 (1999-04-01), None
patent: WO-99/28317 (1999-06-01), None
patent: WO-99/41244 (1999-08-01), None
patent: WO-99/43671 (1999-09-01), None
patent: WO-99/64416 (1999-12-01), None
patent: WO-99/64417 (1999-12-01), None
patent: WO-00/10566 (2000-03-01), None
patent: WO-00/21960 (2000-04-01), None
patent: WO-00/41473 (2000-07-01), None
patent: WO-01/07422 (2001-02-01), None
patent: WO-01/26656 (2001-04-01), None
patent: WO-01/40222 (2001-06-01), None
patent: WO-01/40236 (2001-06-01), None
patent: WO-02/081468 (2001-06-01), None
patent: WO-01/81350 (2001-11-01), None
patent: WO-02/48139 (2002-06-01), None
patent: WO-02/056013 (2002-07-01), None
patent: WO-02/080841 (2002-10-01), None
patent: WO-02/081469 (2002-10-01), None
patent: WO-02/096890 (2002-12-01), None
patent: WO-02/096916 (2002-12-01), None
patent: WO-02/096917 (2002-12-01), None
patent: WO-02/096918 (2002-12-01), None
patent: WO-02/102785 (2002-12-01), None
patent: WO-03/008395 (2003-01-01), None
patent: WO-03/022824 (2003-03-01), None
patent: WO-03/035073 (2003-05-01), None
patent: WO-03/035648 (2003-05-01), None
patent: WO-03/072575 (2003-09-01), None
patent: WO-03/072576 (2003-09-01), None
patent: WO 2004029066 (2004-04-01), None
Pae, A.N., et al., “Synthesis and In Vitro Activity of New Oxazolidinone Antibacterial Agents Having Substituted Isoxazoles,” Bioorganic & Medicinal Chemistry Letters, 9, 2679-2684, (1999).
Park, C.H., et al., “Antibacterials. Synthesis and Structure-Activity Studies of 3-Aryl-2-oxooxazolidines. 4. Multiply-Substituted Aryl Derivatives,” J. Med. Chem., 35, 1156-1165 (1992).
Gregory, W.A., et al., “Antibacterials. Synthesis and Structure-Activity Studies of 3-Aryl-2-oxooxazolidines. 2. The ‘A’ Group,” J. Med. Chem., 33, 2569-2578 (1990).
Skacani, I., et al., “The preparation and fungicidal activity of a series of 1-[(3-arylisoxazolin- or isoxazol-5-yl)methyl]-1H-1,2,4-triazoles,” Chem. Papers, 45(6), 807-815 (1991).

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