Isoxazoline compounds useful as fibrinogen receptor antagonists

Details Isoxazoline compounds useful as fibrinogen receptor antagonists Isoxazoline compounds useful as fibrinogen receptor antagonists

1994-09-12

1995-08-29

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514326, 5142368, 514378, 544137, 546275, 548240, A61K 3144, A61K 3142, C07D26104, C07D41312

Patent

active

054460565

ABSTRACT:
This invention relates to novel isoxazolines which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

REFERENCES:
patent: 5039805 (1991-08-01), Alig et al.
patent: 5187157 (1993-02-01), Kettner et al.
Phillips et al. Cell (1991) 65, 359-362, GP116-111a: The Responsive Integrin.
Hartman et al. J Med Chem (1992) 35 4640-4642, Non-Peptide . . . Exosite Inhibitors.
Alig et al. J Med Chem (1992) 35 4393-4407, Low Molecular . . . Antagonists.

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