Isoxazolidine-3,5-diones, pharmaceutical compositions and method

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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C07C10330

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active

049993666

ABSTRACT:
A method of controlling hyperlipidemia in mammals which comprises adminstering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and the structural formula: ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different provided both are not hydrogen when R.sup.3 is an alkenyl or cycloalkenyl group, are selected from the group consisting of hydrogen; alkyl of 1 to 18 carbons; substituted alkyl of 1 to 18 carbons; cycloalkyl of 4 to 10 ring carbon atoms; substituted cycloalky of 4 to 10 ring carbon stoms; alkoxy of 1 to 8 carbon atoms; amido; carbamoyl; acyloxy; alkoxycarbonyl; halogen, aryl and substituted aryl, or together R.sup.1 and R.sup.2 from a C.sub.3 to C.sub.7 alkylene group; and

REFERENCES:
patent: 4504486 (1989-03-01), Kurkov
patent: 4681893 (1987-07-01), Roth
Manik Lal Debnath-Master's Thesis; "The Reaction of Benzohydroxamic Acids with Dicarboxylic Acid Chlorides in the Synthesis of 2,3-Benzoxazine-1,4-Diones and Isoxazolidine-3,5-Diones", (1985).

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