Isoxazoles as antiviral agents

Details Isoxazoles as antiviral agents Isoxazoles as antiviral agents

1983-10-17

1984-05-29

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548247, A61K 3142, C07D26108

Patent

active

044514760

ABSTRACT:
Compounds of the formulas: ##STR1## wherein R is alkyl, X is O or CH.sub.2, n is an integer from 4 to 8, and Ar is phenyl or substituted phenyl are useful as antiviral agents especially against picornaviruses.

REFERENCES:
patent: 4268678 (1981-05-01), Diana et al.
Kohler et al., "Nitrocyclopropane Derivatives," Chem. Abst., 13: 2682, (1919).
Kochetkov et al., "Isoxazole Series," Chem. Abst., 55: 18707(f), (1961).
Sokolov et al., "Isoxazole Series," Chem. Abst., 65: 8734(e), (1966).
Yukichi et al., "Acetylenic Compounds," Chem. Abst., 68: 12885(j), (1968).
Belgodere et al., "Ultraviolet Spectra of Styrylisoxazoles," Chem. Abst., 79: 91167(e), (1973).
Carb et al., "Isoxazole Antihelmenthics," Chem. Abst., 87: 15689(b), (1977).
Barber et al., ". . . Synthesis Isoxazoles," Chem. Abst., 89: 75360p, (1978).

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