Isoxazoles

Details Isoxazoles Isoxazoles

1994-08-22

1995-12-19

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548248, C07D26330, A61K 3142

Patent

active

054768667

ABSTRACT:
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is cycloalkyl of 3 to 6 carbon atoms; R.sub.4 is selected from the group consisting of halogen, nitrile, nitro, --SCH.sub.3, -alkylcarbonyl of 1 to 6 carbon atoms, cycloalkylcarbonyl of 3 to 6 carbon atoms, --CX.sub.3, --WCX.sub.3, --(CH.sub.2).sub.n CX.sub.3, --(CX.sub.2).sub.n CX.sub.3, --W(CX.sub.2).sub.n CX.sub.3 and a --W(CH.sub.2).sub.n CX.sub.3, in which X is halogen, W is oxygen or sulfur, and n is 1, 2 or 3; and R.sub.5 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and cycloalkyl of 3 to 6 carbon atoms; with the proviso that if R.sub.5 is hydrogen, R.sub.4 is not --SCH.sub.3 or --CF.sub.3 and their non-toxic pharmaceutically acceptable salts having anti-prolifera-tive, anti-inflammatory and anti-tumor activity.

REFERENCES:
patent: 4935434 (1990-06-01), Han
CA 116:128908h Isoxazole . . . antirheumatics, Bartlett et al., p. 890, 1992.
CA 112:55842n Preparation . . . antiarthritics, Han, p. 771-772, 1990.
CA 116:128908h Isoxazole-. . . antirheumatics, Bartlett et al., p. 890, 1992.

Affiliated with

Also associated with

Rating

Isoxazoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isoxazoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isoxazoles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-992300