Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-06-16
2010-12-14
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S255050, C514S256000, C514S341000, C514S378000, C544S060000, C544S405000, C546S272100, C548S247000
Reexamination Certificate
active
07851469
ABSTRACT:
The present invention is concerned isoxazole-imidazole derivatives having affinity and selectivity for GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use for enhancing cognition or for the treatment of cognitive disorders like Alzheimer's disease. In particular, the present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula Iwherein R1, R2and R3are as described in the specification.
REFERENCES:
patent: 4639266 (1987-01-01), Heubach et al.
patent: 2003/0055085 (2003-03-01), Wagener et al.
patent: 2004/0006226 (2004-01-01), Ladduwahetty et al.
patent: 2004/0132755 (2004-07-01), Ledeboer et al.
patent: 3525205 (1986-03-01), None
patent: 2336589 (1999-10-01), None
patent: WO 01/29015 (2001-04-01), None
patent: WO 01/34603 (2001-05-01), None
patent: WO 02/50062 (2002-06-01), None
patent: WO 02/81474 (2002-10-01), None
patent: WO 03/004027 (2003-01-01), None
patent: WO 03/044017 (2003-05-01), None
patent: WO 2005/014553 (2005-02-01), None
patent: WO 2005/118568 (2005-12-01), None
patent: WO 2005/123672 (2005-12-01), None
patent: WO 2006/044617 (2006-04-01), None
patent: WO 2006/069155 (2006-09-01), None
patent: WO 2007/074078 (2007-07-01), None
patent: WO 2007/074089 (2007-07-01), None
patent: WO 2007/082806 (2007-07-01), None
McNamara et al., Psychobiology (1993), vol. 21, pp. 101-108.
Lam et al., Bioorganic & Medicinal Chemistry Letters (2003) vol. 13(10) pp. 1795-1799.
Wang et al., Journal of Fluorine Chemistry, vol. 111(2) pp. 241-246 (2001).
Roy et al., Synthesis, 2003 pp. 1347-1356.
White, et al., Journal of Organic Chemistry (1981), vol. 46(11) pp. 2273-2280.
Shi Shun et al., J. Org. Chem. vol. 68 (2003) pp. 6810-6813.
Burke, et al., Journal of Natural Products, 1986, vol. 49, pp. 522-523.
Hamper et al., J. Agric. Food Chem. (1995), vol. 43, pp. 219-228.
Kumar, et al., Tetrahedron Letters, vol. 47, (2006), p. 1457-1460.
Hormi, Organic Syntheses, vol. 8, p. 247 (1993) & vol. 66, (1988), p. 173.
Andosova et al., Pharmaceutical Chemistry Journal (English Translation), vol. 12, No. 8, 1978, pp. 1019-1022.
Doyle, et al., Journal of the Chem. Society, 1963, pp. 5838-5845.
Anderson, et al., Journal of Organic Chem. vol. 51(6), 1986, pp. 945-947.
Bourbeau et al., Organic Letters, vol. 8(17), 2006, pp. 3679-3680.
Waldo et al., Org. Lett. vol. (7) pp. 5203-5205 (2005).
Austin et al., J. Org. Chem. vol. 46, pp. 2280-2286 (1981).
Schlosser et al., Eur. J. Org. Chem. vol. (24), p. 4181-4184 (2002).
Hüttel et al., Liebigs, Ann. Chem. vol. 593, pp. 200-207 (1955) (English translation).
Seydel et al., J. Med. Chem. vol. (19) pp. 483-492 (1976).
Kirk, K. L., J. Org. Chem. vol. (43) pp. 4381-4383 (1978).
Ley et al., Angew Chem, 2003 vol. 115 p. 5558-5606.
Félix et al., J. Org. Chem. 1995, vol. 60 p. 3907-3909.
Buettelmann Bernd
Jakob-Roetne Roland
Knust Henner
Thomas Andrew
Hoffmann-La Roche Inc.
Johnston George W.
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
Saeed Kamal A
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