Isoxazole derivatives for use as cerebro-active drugs and centra

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5142338, 5142368, 514380, 544137, 544367, 544368, 548241, 548243, 546198, 546209, 546270, 546275, C07D26120, C07D26112, A61K 3142

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053210379

ABSTRACT:
Compounds of formula (I): ##STR1## [in which: either (a) the dotted line ( ) is a single bond; A=is oxygen; and B is a group of formula (II): ##STR2## (in which m is 0 and n is 0 or 1) or (b) the dotted line ( ) is a double bond; A=is said group of formula (II) in which m is 1 and n is 0 or 1; and B is absent; and R.sup.1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, optionally substituted benzyl or optionally substituted phenyl; R.sup.2 is hydrogen, halogen, alkyl, optionally substituted phenyl or heterocyclic; or R.sup.1 and R.sup.2, together with the carbon atoms to which they are attached, are a hydrocarbon ring fused to the isoxazole ring; R.sup.3 and R.sup.4 are each hydrogen, alkyl, optionally substituted benzyl or optionally substituted phenyl; or R.sup.3, R.sup.4 and the nitrogen atom to which they are attached together represent an alicyclic amino group]; and salts thereof may be used for the treatment of cerebral circulatory problems and for use as centrally acting muscle relaxants.

REFERENCES:
Slawik, Acta Pol Pharm. 41 625 (1984).
Chemical Abstracts, vol. 104, No. 7, Feb. 17, 1986, p. 516, Abstract No. 50810 (published in USA).
Patent Abstracts of Japan, vol. 5, No. 89 (C-58), [761], Jun. 10, 1981 (published in Japan).
Chemical Abstracts, vol. 88, No. 9, Feb. 27, 1978, p. 388, Abstract No. 62379f (published in USA).
Chemical Abstracts, vol. 101, No. 1, Jul. 2, 1984, p. 605, Abstract No. 7077t (published USA).
Chem. Abstract, 95-97779H (1981) (published in USA).

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