Isoxazole derivatives for the treatment of irritable bowel syndr

Details Isoxazole derivatives for the treatment of irritable bowel syndr Isoxazole derivatives for the treatment of irritable bowel syndr

1993-04-20

1995-07-18

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514379, 514380, A61K 3142

Patent

active

054341744

ABSTRACT:
Methods of treating Irritable Bowel Syndrome (IBS) using a series of isoxazole derivatives that have both 5-HT1A agonist and M1 muscarinic activities, and formulations adapted for the treatment of IBS comprising those derivatives.

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Bazzocchi, et al., Curr. Ther. Res. Clin. Exp., 52(1), 135 (1992).
Chem. Abst., 115(3), 28923v (1991).
Chem. Abst. 115(3), 28924w (1991).
C. J. Fowler, et al., Life Sciences, 48:959-967 (1990).
Gerald Friedman, MD. Gastroenterology Clinics of North America, 20:325-333 (1991).
Tonini et al., "5-Hydroxytryptamine.sub.4 Receptor Agonists Facilitate Chloinergic Transmission . . . ", Life Sciences, vol. 50, (1992) pp. Ll-173-PL-178.

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