Isoxazole derivatives and process for producing the same

Details Isoxazole derivatives and process for producing the same Isoxazole derivatives and process for producing the same

2004-09-02

2008-03-11

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S241000

Reexamination Certificate

active

07342036

ABSTRACT:
The present invention provides isoxazole derivatives represented by the following formula (I):(wherein R1represents a hydrogen atom, C1-C20hydrocarbon group or —C(═O)OR1a(wherein R1arepresents a C1-C10alkyl group, etc.); R2and R3represent a hydrogen atom, halogen atom, hydroxy group, C1-C20alkyl group or C6-C20aryl group, etc.; R4represents a hydrogen atom, halogen atom, hydroxy group, cyano group, nitro group, amino group, C1-C20hydrocarbon group, C1-C10alkoxy group, C1-C10acyl group, 5- to 7-membered heterocyclic group, etc.; R5represents a hydrogen atom, halogen atom, hydroxy group, optionally substituted C1-C20hydrocarbon group, C1-C20alkoxy group, 5- to 7-membered heterocyclic group, etc.; and, n represents 0, 1, 2, 3 or 4), and a process of producing the same. The compounds are useful as intermediates for synthesis of pharmaceutical compounds, agricultural chemicals, dye compounds, etc. having the isoxazole skeleton.

REFERENCES:
patent: 401779 (1990-12-01), None
patent: 474012 (1992-03-01), None
patent: 2 284 600 (1995-06-01), None
Easton, C.J. et al., Reversal of Regiochemistry in the Synthesis of Isoxazoles by Nitrile Oxide Cycloadditions, Tetrahedron Letters, 1994, vol. 35, No. 21, pp. 3589 to 3592, formula 3a, scheme 1.
“Electrochemical and yeast-catalysed ring-opening of isoxazoles in the synthesis of analogue of the herbicide Grasp®” by Easton et al., Journal of the Chemical Society, Perkin Transactions 1, vol. 10, 2001, pp. 1168-1174.
Supplementary European Search Report for EP 02 79 2015 completed Oct. 19, 2005.

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