Isoxazole derivatives and methods of treating nitric oxide...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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11093182

ABSTRACT:
A series of isoxazole derivatives and methods of suppressing, inhibiting, or preventing disorders mediated by nitric oxide (NO) and/or proinflammatory cytokines, such as TNF-α (tumor necrosis factor alpha), IL-1 (interlukin-1), and IL-6, are described.

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CA Registry No. 717866-68-7, entry date into the Registry file on STN is Jul. 28, 2004.
CA Registry No. 717858-34-9, entry date into the Registry file on STN is Jul. 28, 2004.
CA Registry No. 688051-07-2, entry date into the Registry file on STN is Jun. 1, 2004.
Svab et al., CA 100:82623, 1984.
Svab et al., Cesko-Slovenska Farmacie, (1983), 32(9-10), pp. 316-322.
Miljkovic, Dj. et al., “Leflunomide Inhibits Activation of Inducible Nitric Oxide Synthase in Rat Astrocytes,”Brain Research, 2001, 889, 331-338.

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