Isoxazole compounds as cyclooxygenase inhibitors

Details Isoxazole compounds as cyclooxygenase inhibitors Isoxazole compounds as cyclooxygenase inhibitors

1996-08-14

1999-01-12

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5462721, 548243, 548245, 548248, C07D26106

Patent

active

058592571

ABSTRACT:
A class of substituted isoxazolyl compounds is described for use in treating cyclooxygenase-2 related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3, are described in the specification.

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Ichiro Yamawaki et al, Chem. Pharm. Bull., 36:3142-3146 (1988).
Umezawa et al, Cbem., vol. 36, No. 9, pp. 1150-1154, Sep. 1963.
Descamps et al, Bull. Soc. Chim. Belg., 73:459-482 (1964).

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