Isoxazole and isothiazole compounds for the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S245000, C548S246000

Reexamination Certificate

active

10843939

ABSTRACT:
The present invention relates to compounds of the Formulawherein R1, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X, Y, Z and n are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.

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patent: WO 04 033434 (2004-04-01), None
patent: WO 04 033439 (2004-04-01), None
patent: WO 92 21360 (2004-12-01), None
Thompson et al., Current Medicinal Chemistry, Oct. 2002, 9(19), pp. 1751-1762.
Brown, Neurology, Jun. 25, 2002, 58(12), pp. 1720-1725.
Zinnes, Harold et al, Isoxicam and related 4-hydroxy-N-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxides. Potent nonsteroidal antiinflammatory agents, Journal of Medicinal Chemisty, (25)1, 12-18, CODEN:JMCMAR; ISSN:0022-2623, 1982, XP002292360.

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