Isoxazole-and isothiazole-amine compounds for the treatment...

Details Isoxazole-and isothiazole-amine compounds for the treatment... Isoxazole-and isothiazole-amine compounds for the treatment...

2007-05-22

2007-05-22

McKane, Joseph K. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S378000

Reexamination Certificate

active

11078862

ABSTRACT:
The present invention relates to compounds of the Formula Iwherein R1, R3, R5, R6, R7, X and Y are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods of treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.

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patent: 2004/0171643 (2004-09-01), De Cointet et al.
patent: 2004/0242666 (2004-12-01), Chen
Uyeo et al. Abstract from: Yakugaku Zasshi 1963, 83, 198-200. * CAS Abstract attached.
International Search Report PCT/IB2005/000792.
Uyeo, Shojiro et al, Synthesis of 5-(Aminoacylamido)-3-Methylisothiazole Derivatives and Their Analgesic Action, 1963, 83, pp. 195-197.
Takahashi, Torizo et al., Synthesis of Analgesics. XXVII. Synthesis and Pharmacological Action of Isoxazole Derivatives. 1, 1962, 82, pp. 474-480.

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