Isoxazole and crotonamide derivatives and their use as pharmaceu

Details Isoxazole and crotonamide derivatives and their use as pharmaceu Isoxazole and crotonamide derivatives and their use as pharmaceu

1999-04-22

2000-09-19

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25517

Patent

active

061214795

ABSTRACT:
A compound of the formula ##STR1## where R.sup.1 is the radical of the formula II or III ##STR2## is suitable for the production of a pharmaceutical for the treatment of inflammations, carcinomatous diseases, or autoimmune diseases. A compound of the formula IV ##STR3## is suitable for the production of specific antibodies against a compound of the formula I for the discovery of specific-binding proteins from cell extracts, serum, blood, or synovial fluids, for the purification of proteins, for the modification of microtiter plates, or for the preparation of chromatography material, in particular of affinity chromatography material, and for use in diagnostics.

REFERENCES:
patent: 4284786 (1981-08-01), Kammerer et al.
patent: 4965276 (1990-10-01), Bartlett et al.
patent: 5308865 (1994-05-01), Bartlett et al.
patent: 5494911 (1996-02-01), Bartlett et al.
patent: 5547970 (1996-08-01), Weithmann et al.
patent: 5744664 (1998-04-01), Brekner et al.
patent: 5747664 (1998-05-01), Schleyerbach et al.
G. Panayotou et al., "Riding the Evanescent Wave", Current Biology, vol. 3, No. 12, pp. 913-915, 1993.
Kurtz et al., "Leflunomide: an active antiinflammatory and antiproliferative agent in models of dermatologic disease", Chemical Abstracts, vol. 123, No. 19, Nov. 6, 1995, p. 57.
Robertson et al., "Leflunomide: inhibition of A-antigen induced autoimmune uveitis in Lewis rats", Chemical Abstracts, vol. 122, No. 5, Jan. 30, 1995, pp. 68-69.
Thoss et al., "Immunomodulation of rat antigen-induced arthritis by leflunomide alone and in combination with cyclosporin", Chemical Abstracts, vol. 124, No. 19, May 6, 1996, p. 108.
Dias et al., "Measurement of the active leflunomide metaboite (A 77 1726) by reverse-phase high-performance liquid chromatography", Chemical Abstracts, vol. 122, No. 15, Apr. 10, 1995, p. 9.

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