Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, p

Details Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, p Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, p

1995-06-07

1996-07-02

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142268, 514256, 5142288, 514275, 514326, 514340, 514619, 514626, 544322, 544326, 544328, 544330, 544331, 544 54, 544 55, 544 96, 546209, 546245, 546226, 5462721, 546309, 548248, 564194, 564195, 564196, 564197, A61K 3141, C07D26102

Patent

active

055322590

ABSTRACT:
Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
Isoxazole-4-carboxamide derivatives and hydroxyalkylidene-cyanoacetamide derivatives are suitable for the treatment of carcinoses. These compounds can be prepared by known processes. Some of the compounds are novel and are additionally suitable for the treatment of rheumatic disorders.

REFERENCES:
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patent: 4087535 (1978-05-01), Heubach
patent: 4892963 (1990-01-01), Gallagher et al.
Robert R. Bartlett, "Immunopharmacological Profile of HWA 486, a Novel Isoxazol Derivative-II. In Vivo Immunomodulating Effects Differ From Those of Cyclophosphamide, Prednisolone, or Cyclosporin A," Int. J. Immunopharmac., vol. 8, No. 2, pp. 199-204, 1986.
R. R. Bartlett et al., "Development of Autoimmunity in MLR/LPR Mice and the Effects of Drugs on this Murine Disease," Scand. J. Rheumatology 1988; Suppl. 75: 290-299.
Chemotherapy of Cancer, Second Ed., Carter et al., John Wiley & Sons, pp. 364-365, 1981.

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