(Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical u

Details (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical u (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical u

1985-01-22

1985-12-31

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544137, 544367, 548248, 514240, 514255, 514378, A61K 3142, A61K 31535, C07D26106, C07D41306

Patent

active

045621870

ABSTRACT:
There are disclosed novel compounds having the formula ##STR1## where each X is independently hydrogen, halogen (F, Cl, Br or I), loweralkyl or loweralkoxy; m is 1 or 2; R' is hydrogen or loweralkyl; and R is ##STR2## n being 1, 2 or 3, each of R.sub.1 and R.sub.2 being independently hydrogen or loweralkyl and R.sub.3 being ##STR3## an optical antipode thereof or a pharmaceutically acceptable acid addition salt thereof, which are useful as antihypertensive, analgesic and antiinflammatory agents, methods for synthesizing them, and pharmaceutical compositions comprising an effective amount of such a compound.

REFERENCES:
patent: 4247548 (1981-01-01), Yoshimoto et al.
Sasaki et al., Bull. Chem. Soc. Japan, vol. 44, (1971), pp. 185-189.

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