Isotopically tagged synons from 2 carbon precursors

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

Reexamination Certificate

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C568S028000, C568S038000, C568S058000, C568S059000, C568S581000

Reexamination Certificate

active

08034982

ABSTRACT:
The use of vinyl sulfides, sulfoxides and sulfones in synthetic chemistry for the production of a wide variety of materials is well known. For example, phenyl vinyl sulfides, sulfoxides and sulfones have been used for the synthesis of important heterocycles, in combinatorial chemistry and as Diels-Alder adducts. Although these compounds have been used extensively for a variety of applications, the isotopically labeled versions have not been reported. A simple route for the isotopically labeled production of these important building blocks has been developed.

REFERENCES:
patent: 2003/0158445 (2003-08-01), Martinez et al.
patent: 2001039924 (2001-02-01), None
Grue-Soerensen et al., {Biosynthetic Route to the Ephedra Alkaloids, Journal of the American Chemical Society (1994), 116(14), 6195-200}.
Bartuska et al., {Carbon-13-carbon-13 coupling constants. IV. Isopropenyl system, Journal of Magnetic Resonance (1969-1992) (1972), 7(1), 36-47}.
Dijkstra et al., {Rearrangements and fragmentations of phenyl styryl sulfides, Organic Mass Spectrometry (1982), 17(9), 430-8}.
Proctor, David J., The Synthesis of Thiols, Selenas, Sulfides, Selenides, Sulfoxides, Selenoxides, Sulfones and Selenones; In J. Chem. Soc., Perkin Trans. 1999; 1:641-667.
PCT—Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration, Date of Mailing Jul. 25, 2008.

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