Isotopically marked quinoline derivatives as adenosin A3...

Details Isotopically marked quinoline derivatives as adenosin A3... Isotopically marked quinoline derivatives as adenosin A3...

2011-06-21

2011-06-21

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S159000

Reexamination Certificate

active

07964731

ABSTRACT:
The invention relates to adenozin A3receptor ligands labeled with iodine isotops of mass number 125, within those favorably to antagonists and their isomers, to the experimental materials containing them, to a process for the preparation of the compounds of the general formula (I)and their isomers, to the new intermediates of the general formula (II)and to the preparation thereof.

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Van Galen P.J.M. et al., “A Binding Site Model and Structure-Activity Relationships for the Rat A3Adenosine Receptor”,Molecular Pharmacology45(6):1101-1111 (1994).
Olah M.E. et al., “1-4-Aminobenzyl-5′-N-Methylcarboxamidoadenosine, a High Affinity Radioligand for the Rat A3Adenosine Receptor”,Molecular Pharmacology45(5):978-982 (1994).
Stiles G.L. et al., “The A1Adenosine Receptor”,The Journal of Biological Chemistry260(19):10806-10811 (1985).

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