Isotopically-labeled polycyclic amine derivatives

Details Isotopically-labeled polycyclic amine derivatives Isotopically-labeled polycyclic amine derivatives

1990-01-17

1990-10-02

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

564308, A61K 4902, C07C21100

Patent

active

049608150

ABSTRACT:
##STR1## A series of isotopically-labeled fluorenamine, dibenzofuranamine, and dibenzothiophenamine derivatives useful for diagnosing neurodegenerative disorders in mammals wherein a detectable amount of an isotape-labeled fluorenamine, dibenzofuranamine, or dibenzothiophenamine derivative is used.

REFERENCES:
patent: 3111527 (1963-11-01), Godefroi
patent: 3159677 (1964-12-01), Godefroi
Drug Development for Senile Cognitive Decline, J. Med. Chem., 1986, 29, 1125, Hershenson, et al.
Chapter 4, Cognitive Disorders, Annual Reports in Medicinal Chemistry-21, 1986, Hershenson, et al.
Developmental Neuropsychology, 1986 2(4), 261-276.
Neuroscience Letters, 74 (1987) 371-376.
European Journal of Pharmacology, 123 (1986) 173-174.
Science, vol. 227, Alteratins in 1-Glutamate Binding in Alzheimer's and Huntington's Diseases.
Godefroi et al "t-Carbinamines Derived from Pardaur Hydrogenated Fluorenes and Dibenzofucanes", J. Org. Chem. vol. 28, (1967), pp. 1112-1119.
Godero et al., "t-Carbinamines Derived from Partially Hydrogenated Fluorenes and Dibenzofuranes," J. Org. Chem., vol. 28, (1963), pp. 1112-1119.

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