Isotopically labeled chemically stable reagents and process...

Details Isotopically labeled chemically stable reagents and process... Isotopically labeled chemically stable reagents and process...

2004-05-28

2011-11-15

Kosack, Joseph (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonate esters

Reexamination Certificate

active

08058464

ABSTRACT:
A radioisotope labeled reagent includes a compound having the general formula (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R1SO2—O—, R1—S—,12C1H3(12C1H2)n—S—R1C(O)O—, NC—, (R1)3P—, XMg— and Li—, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R1is H, aryl, a substituent containing aryl, C1-C20alkyl, a substituent containing C1-C20alkyl, C2-C20alkenyl, a substituent containing C2-C20alkenyl, C2-C20alkynyl, and a substitute containing C2-C20alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R1in R1-S is not aryl.in-line-formulae description="In-line Formulae" end="lead"?L-(aCbH2)naCbH3  (I)in-line-formulae description="In-line Formulae" end="tail"?

REFERENCES:
patent: 4269777 (1981-05-01), De Luca et al.
patent: 6713044 (2004-03-01), Martinez et al.
patent: 56-500538 (1981-04-01), None
Lee et al. “Substituent Effects on Transition-state Structures for Dissociative and Associative Sn2 Reactions” J. Chem. Soc. Perkin Trans. 1991, pp. 1741-1746.
Gragerov, CAS Accession No. 1955:63263.
Llewellyn et al. “Some Deuterium Isotope Effects: I. Water Solvolysis of Methyl-d3 Esters” Canadian Journal of Chemistry, 1960, vol. 38, pp. 222-232.
Bailey et al. CAS Accession No. 1989:212048, 1989.
Nefedov et al. Beilstein Registry No. 4368300, 1980.
Nefedov et al. Beilstein Registry No. 4367300, 1980.
Pounds, Scot Preparation of carrier-free [methyl-3H] methyl nosylate and its use as a radiochemically-stable methylating reagent; Proceedings of the International Symposium, Boston, MA Jun. 1-5, 2003; XP002401240.
Pounds, Scot Preparation of carrier-free [methyl-3H] methyl nosylate and its use as a radiochemically-stable methylating reagent; Proceedings of the International Symposium, Boston, MA Jun. 1-5, 2003; XP002401241.
Bellstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Chem Soc. Perkin Trans 2, 1991 pp. 1741-1746; XP002401242.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Chem Soc. Perkin Trans 1, vol. 12 1984, pp. 2919-2925; XP002401243.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Chem Heterocycl. Compd. vol. 20, No. 6, 1984 pp. 637-642; XP002401244.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Chem Soc. Perkin vol. 77, 1955 pp. 5515-5517; XP002401245.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Chem Soc. Perkin vol. 99, 1977 pp. 851-857; XP002401246.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, Can J. Chem vol. 32, 1954 p. 1; XP002401247.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, Can J. Chem, USSR, vol. 34, 1956 p. 179; XP002401248.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Org. Chem USSR, vol. 16, 1980 pp. 1944-1946; XP002401249.
Bellstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Org. Chem USSR, vol. 16, 1980 pp. 1944-1946; XP002401250.
Beilstein Institut Zur Poerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Phys. Chem, vol. 88, No. 9, 1984 pp. 1701-1706; XP002401251.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. AM. Chem Soc. vol. 103, No. 1, 1981 pp. 36-39; XP002401252.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Chem Soc. Perkin Trans., 19804, pp. 2902-2913; XP002401253.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, Biosci. Biotechnol. Biochem, vol. 60, No. 9, 1996, pp. 1460-1463; XP002401254.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften, Frankfurt AM Main, Chem. Pharm. Bull., vol. 44, No. 6, 1996, p. 12481249; XP002401255.
Ault, Bruce S., Infrared matrix isolation study of magnesium metal atom reactions. Journal of the American Chemical Society, 1980, p. 3491, XP002401219.
Mayo, D. W. et al., The application of resolution enhancement techniques to the study of factors affecting group frequencies,Spectrochmica Acta, Part A: Molecular and Biololecular Spectroscopy, 1985, pp. 355-356; XP002401220.
Sy, L.-K. e al., Syntheses of dihydroertemisinic acid and dihydro-epi-deoxyarteannuin B Incorporating a stable isotope label at the 15-position for studies into the biosynthesis of artemisinin, p. 8498, 8506, col. 1, XP002401121.
Beilstein Institut Zur Poerderung Der Chemischen Wissenschaften, Frankfurt AM Main, Synth. Commun., vol. 25, No. 17, 1995 pp. 2685-2694. XP002401256.
Bellsteln Institut Zur Poerderung Der Chemischen Wissenschaften, Frankfurt AM Main, J. Labelled Compd, Radlopherm vol. 45, No. 5, 2002, pp. 401-406; XP002401257.
Scot Pounds; Preparation of carrier-free [methyl-3H] methyl nosylate and its use as a radiochemically-stable methylating reagent; Database Accession No. 2004:859485; Synthesis and Applications of Isotopically Labelled Compounds, Proceedings of the International Symposium; 8th, Boston, MA; United States, (2004); XP-002401240.
Scot Pounds; Preparation of carrier-free [methyl-3H] methyl nosylate and its use as a radiochemically-stable methylating reagent; Database Accession No. 2004:859381; Synthesis and Applications of Isotopically Labelled Compounds, Proceedings of the International Symposium; 8th, Boston, MA; United States, (2004); XP-002401241.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 4875789; J. Chem. Soc. Perkin Trans. 2, 1991; XP-002401242.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 2379871; J. Chem. Soc. Perkin Trans. 1, vol. 12, 1984; XP-002401243.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 4682440; Chem. Heterocycl. Compd., vol. 20, No. 6, 1984; XP-002401244.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 2651782; J. Am. Chem. Soc., vol. 77, 1955; XP-002401245.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 2861936; J. Am. Chem. Soc., vol. 99, 1977; XP-002401246.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 1753621; Can. J. Chem., vol. 32, 1954; XP-002401247.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 1762191; Can. J. Chem., vol. 34, 1956; XP-002401248.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 4368300; J. Org. Chem. USSR, vol. 16, 1980; XP-002401249.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 4367300; J. Org. Chem. USSR, vol. 16, 1980; XP-002401250.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 1927100; J. Phys. Chem., vol. 88, No. 9,1984; XP-002401251.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 4961534; J. Am. Chem. Soc., vol. 103, No. 1, 1981; XP-002401252.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 4964579; J. Am. Chem. Soc. Perkin Trans.; XP-002401253.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Database Accession No. 3560149; J. Biosci. Biotechnol. Biochem., vol. 60, No. 9; 1996.; XP-002401254.
Beilstein Institut Zur Foerderung Der Chemischen Wissenschaften; Frankfurt AM Main, DE: Datab

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