Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2007-12-11
2007-12-11
Richter, Johann (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S392000, C544S398000, C544S399000
Reexamination Certificate
active
10751388
ABSTRACT:
In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines.
REFERENCES:
patent: 3860581 (1975-01-01), Nudelman et al.
patent: 5780232 (1998-07-01), Arlinghaus et al.
patent: 6027890 (2000-02-01), Ness et al.
patent: 6156527 (2000-12-01), Schmidt et al.
patent: 6312893 (2001-11-01), Van Ness et al.
patent: 6319476 (2001-11-01), Victor, Jr. et al.
patent: 6329180 (2001-12-01), Garvin
patent: 6403309 (2002-06-01), Iris et al.
patent: 6428956 (2002-08-01), Crooke et al.
patent: 6472156 (2002-10-01), Wittwer et al.
patent: 6613508 (2003-09-01), Ness et al.
patent: 6629040 (2003-09-01), Goodlett et al.
patent: 6750061 (2004-06-01), Chait et al.
patent: 6824981 (2004-11-01), Chait et al.
patent: 7045296 (2006-05-01), Parker et al.
patent: 2002/0119456 (2002-08-01), Ness et al.
patent: 2003/0077595 (2003-04-01), Van Ness et al.
patent: 2005/0049406 (2005-03-01), Lerchen et al.
patent: 0209763 (1986-07-01), None
patent: 0261804 (1987-08-01), None
patent: 1027454 (1998-01-01), None
patent: 0990047 (1998-07-01), None
patent: 01125357 (1989-05-01), None
patent: WO94/15944 (1994-07-01), None
patent: WO98/15648 (1996-12-01), None
patent: WO97/11958 (1997-04-01), None
patent: WO98/31830 (1998-06-01), None
patent: WO98/32876 (1998-07-01), None
patent: WO99/05319 (1999-05-01), None
patent: WO00/11208 (2000-03-01), None
patent: WO01/68664 (2001-09-01), None
patent: WO01/86296 (2001-11-01), None
patent: WO02/14867 (2002-02-01), None
patent: WO03/001206 (2003-01-01), None
patent: WO03/025576 (2003-03-01), None
patent: WO03/040288 (2003-05-01), None
patent: WO03/077851 (2003-09-01), None
patent: WO2004/070352 (2004-08-01), None
patent: WO2004/086050 (2004-10-01), None
patent: WO2005/068446 (2005-07-01), None
Aebersold, R. et al. “Mass Spectrometry in Proteomics”. Chem Rev. 101, 269-295 (2001).
Al-Shahrour, F. et al. “FatiGO: A Web Tool For Finding Significant Associations of Gene Ontology Terms With Groups of Genes (fatigo.bioinfo.cnio.es)”. Bioinformatics, 20, 578-580 (2004).
Alving, K. et al. “Characterization of O-Glycosylation Sites in MUC2 Glycopeptides by NanoElectrospray QTOF Mass Spectrometry”. Journal of Mass Spectrometry, 34, 395-407 (1999).
Anderegg, R. et al. “Mass Spectrometric Characterization of a Protein-Ligand Interaction”. J. Am. Chem. Soc., 117, 1374-1377 (1995).
Banks, R.E. et al. “Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular endothelial growth factor receptor, Flt-1”. Molecular Human Reproduction, 4, 377-386 (1998).
Bates, G. et al, Selective and Direct Activation of O-Esters. Conversion of Phenyl and 2,2,2-Trifluoroethyl Esters Into Acyl Imidazolides. Tetrahedron Letters, 49, 4423-4426 (1976).
Beck-Sickinger, A. et al. “Epitope mapping: synthetic approaches to the understanding of molecular recognition in the immune system”. Pharmaceutical ACTA Helvetiac, 68, 3-20 (1993).
Benard, P. et al. “Homogeneous Multiplex Genotyping of Hemochromatosis Mutations with Fluorescent Hybridization Probes”. American Journal of Pathology, 4, 1055-1061 (1998).
Biemann, K. et al. “Primary Structure of Peptides and Proteins”. Biological Mass Spectrometry, 275-297 (1994).
Biswas, A. et al, “Rearrangement of N-(p-Toluenesulfonyloxy)-2-Pyrrolidinone”. Heterocycles, 11, 2849-2851 (1987).
Chase B.H. et al, “The Synthesis of C-Labelled Diethylcarbamazine, 1-Diethylcarbamyl-4-methylpiperazine (“Hetrazan”) ”. The Journal of The Chemical Society, 3874-3877 (1953).
Chu, Y. et al. “Affinity Capillary Electrophoresis-Mass Spectrometry for Screening Combinatorial Libraries”. J. Am. Chem. Soc. 118, 7827-7835 (1996).
Chu, Y. et al. “Free Solution Identification of Candidate Peptides from Combinatorial Libraries by Affinity Capillary Electrophoresis/Mass Spectrometry”. J. Am. Chem. Soc. 117, 5419-5420 (1995).
Chu, Y. et al. “Using Affinity Capillary Electrophoresis To Identify the Peptide in a Peptide Library that Binds Most Tightly to Vancomycin”. J. Org. Chem. 58, 648-652 (1993).
Cotterill, L. et al. “Qa-1 interaction and T cell recognition of the Qa-1 determinant modifier peptide”. Eur. J. Immunol,- 27, 2123-2132 (1997).
Dunayevskiy, Y. et al, “Application of capillary electrophoresis-electrospray ionization mass spectrometry in the determination of molecular diversity”. Proc. Natl. Acad. Sci. USA, 93, 6152-6157 (1996).
Ecker, D. et al. “Combinatorial Drug Discovery: Which Methods Will Produce the Greatest Value?” Biotechnology, 13, 351-360 (1995).
Eng, J. et at. “An Approach to Correlate Tandem Mass Spectral Data of Peptides With Amino Acid Sequences in a Protein Database”. J. Am. Soc. Mass Spectrom., 5, 976-989 (1994).
Epton, R. “Peptides. Synthesis. Solid Phase Methods”. Innovation and Perspectives in Solid Phase Synthesis. 57-63 (1990).
Fatica, A. et al. “Making Ribosomes”. Curr. Opin. Cell Biol., 14, 313-318 (2002).
Gao, J. et al. “Screening Derivated Peptide Libraries for Tight Binding Inhibitors to Carbonic Anhydrase II by Electrospray Ionization-Mass Spectrometry.” J. Med. Chem. 39, 1949-1955 (1996).
Geysen, H. et al. “Isotope or mass encoding of combinatorial libraries”. Chemistry & Biology, 3, 679-688 (1996).
Gerber, S.A. et al. “Absolute Quantification of Proteins and Phosphoproteins From Cell Lysates by Tandem MS”. Proc. Natl. Acad. Sci., 100, 6940-6945 (2003).
Goodlett, D. et al. “Reduced Elution Speed Detection for Capillary Electrophoresis/Mass Spectrometry”. J. Microl Sep, 5, 57-62 (1993).
Gonzalez, C.I. et al. “Nonsense-mediated mRNA Decay inSaccharomyces cerevisiae”. Gene, 274, 15-25 (2001).
Goshe, M.B. et al. “Stable Isotope-Coded Proteomic Mass Spectrometry”. Curr Opin Biotechnol., 14, 101-109 (2003).
Griffin, T.J. et al. “Complementary Profiling of Gene Expression at the Transcriptome and Proteome Levels inSaccharomyces cerevisiae”. Mol. Cell Proteomics, 1, 323-333 (2002).
Gygi, S.P. et al. “Correlation Between Protein and mRNA Abundance In Yeast”. Mol. Cell Biol., 19, 1720-1730 (1999).
Gygi S.P. et al. “Quantitative Analysis of Complex Protein Mixtures Using Isotope-Coded Affinity Tags”. Nat. Biotechnol., 17, 994-999 (1999).
Ham, S. et al. “HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading”. Current Biology, 7, 950-957 (1997).
Han, D.K. et al. “Quantitative Profiling of Differentiation-induced Microsomal Proteins Using Isotype-Coded Affinity Tags and Mass Spectrometry”. Natl. Biotechnol., 19, 946-951 (2001).
Hanley, S. et al. “Re-evaluation of the primary structure ofRalstoniaeutropha phasing and implifications for polyhydroxyalkanoic acid granule binding”. FEBS Letters, 447, 99-105 (1999).
Harris et al. “An Improved Synthesis of 1-Methyl-2,5-piperazinedione”. J. Heterocyclic Chem. 18, 423-424 (1981).
He, F. et al. Genome-Wide Analysis of mRNA's Regulated by the Nonsense-mediated and 5′to 3′ mRNA Decay Pathways in Yeast. Mol. Cell, 12, 1439-1452 (2003).
Henion, J. et al. “Mass Spectrometric Investigations of Drug-Receptor Interactions”. Therapeutic Drug Monitoring, 15, 563-569 (1993).
Henry, N.L. et al, Purification and Characterization of Yeast RNA Polymerase II General Initiation Factor g. J. Biol. Chem. 267, 23388-23392 (1992).
Hentze, M.W. et al. “A Perfect Message: RNA Surveillance And Nonsense-Mediated Decay”. Cell, 96, 307-310 (1999).
Hermanson, G. et al. “The Chemistry of Reactive Groups”. Bioconjugate Techniques, Chapter 2, 137-165.
Heyes, M. et al. “(18O) Quinolinic Acid: Its Esterification without Back Exchange for Use a
Coull James M.
Pappin Darryl J. C.
Pillai Sasi
Applera Corporation
Richter Johann
Sackey Ebenezer
LandOfFree
Isotopically enriched N-substituted piperazines and methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isotopically enriched N-substituted piperazines and methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isotopically enriched N-substituted piperazines and methods... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3826561