Isotopic tracer composition and method for making and using same

Details Isotopic tracer composition and method for making and using same Isotopic tracer composition and method for making and using same

1991-01-22

1993-05-04

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

206569, A61K 4300, B65D 6900

Patent

active

052080072

ABSTRACT:
An isotopic tracer composition and methods of making and using same for radiological evaluation of body functions and diseases in a subject and for radiological therapy. The isotopic tracer composition comprises a protein carrier agent such as fibrinogen, antibodies, enzymes or portions thereof, bound to a radioisotope which has been reduced to a lower oxidation state by stannous phosphate at a pH of greater than 7. Some suitable radioisotopes are isotopes of technetium, rhenium and ruthenium.

REFERENCES:
patent: 3872226 (1975-03-01), Haney et al.
patent: 4024233 (1977-05-01), Winchell et al.
patent: 4057617 (1977-11-01), Abramovici et al.
patent: 4094965 (1978-06-01), Layne et al.
patent: 4293537 (1981-10-01), Wong
patent: 4401647 (1983-08-01), Krohn et al.
patent: 4418052 (1983-11-01), Wong
patent: 4424200 (1984-01-01), Crockford et al.
patent: 4460561 (1984-07-01), Goldberg
patent: 4622420 (1986-11-01), Meares et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4745076 (1988-05-01), Muller et al.
8 Methods in Enzymology, 44-49 (1966).
9 Methods in Enzymology, 20-29 (1966).
25 Methods in Enzymology, 399 & 415 (1972).
NM/MIRD Pamphlet No. 10, Society of Nuclear Medicine, 5-14 (1975).
NM/MIRD Pamphlet No. 11, Society of Nuclear Medicine, 5-12 (1975).
Shihab-Eldin, et al., Table of Isotopes, 7th ed., 1175, 1178, 1193 & 1194 (1978).
O. Jeghers, et al., "A Chemical Method for the Labeling of Fibrinogen with .sup.99m Tc", European Journal of Nuclear Medicine, 3: 95-100 (1978).
T. Hale, et al., ".sup.99m Tc-Fibrinogen as a Thrombus-Imaging Agent", European Journal of Nuclear Medicine, 3: 267 (1978).
M. H. Jonckheer, et al., "The Interpretation of Phlebograms Using Fibrinogen Labeled with 99m Tc", European Journal of Nuclear Medicine, 3: 223-238 (1978).
L. DeRiemer, et al., "BLEDTA: Tumor Localization by a Bleomycin Analogue Containing a Metal-Chelating Group", Journal of Medicinal Chemistry, 22(9): 1019-1023 (1979).
W. Pettit, et al., "Improved Protein Labeling by Stannous Tartrate Reduction of Pertechnetate", The Journal of Nuclear Medicine, 21(1): 59-62 (1980).
The Journal of Nuclear Medicine 21(6): P79 (1980).
"97-Ru-Para-Butyl-Ida (97-RU-BIDA) as an Agent for Delayed Studies of the Biliary Tract", The Journal of Nuclear Medicine 21(6): P8 (1980).
E. R. Schachner, et al., "Ruthenium-97 Hepatobiliary Agents for Delayed Studies of the Biliary Tract, I: Ru-97 PIPIDA: Concise Communication", Journal of Nuclear Medicine, 22(4): 352-357 (1981).
Z. H. Oster, et al., "Ruthenium-97 DTPA: A New Radiopharmaceutical for Cisternography", The Journal of Nuclear Medicine 22(3): 269-273 (1981).
73 Methods in Enzymology, 154-157 (1981).
M. Thakur, "Cell Labeling: Achievements, Challenges, and Prospects", The Journal of Nuclear Medicine 22(11): 1011-1012 (1981).
S. Vallabhajosula, et al., "Radiochemical Analysis of Tc-99m Human Serum Albumin with High-Pressure Liquid Chromatography: Concise Communication", The Journal of Nuclear Medicine, 23(4): 326-329 (1982).
B. Khaw, et al., "Technetium-99m Labeling of Antibodies to Cardiac Myosin Fab and to Human Fibrinogen", The Journal of Nuclear Medicine, 23(11): 1011-1019 (1982).
E. Sundrehagen, "Formation of .sup.99m Tc-Immunoglobulin G Complexes Free from Radiocolloids, Quality Controlled by Radioimmunoelectrophoresis", European Journal of Nuclear Medicine, 7: 549-552 (1982).
E. Sundrehagen, "Formation of Reduced .sup.99m Tc by Concentrated Hydrochloric Acid and Vacuum Evaporation", International Journal of Applied Radiation and Isotopes, 33: 89-91 (1982).
E. Sundrehagen, "Formation of .sup.99m Tc-Plasmin in Presence of Gentisic Acid Using .sup.99m Tc Pretreated with Concentrated Hydrochloric Acid and Vacuum Evaporation", International Journal of Applied Radiation and Isotopes, 33: 93-97 (1982).
Technetium in Chemistry and Nuclear Medicine, 3-17, 19-23, 25-26 (1983).
"Re-186 HEDP: A Potential Therapeutic Bone Agent", The Journal of Nuclear Medicine 24(5): P125 (1983).
The Journal of Nuclear Medicine 25(5): P127 (1984).
"Design and Evaluation of New Ruthenium Labeled Radiopharmaceuticals for the Pancreas and Heart", The Journal of Nuclear Medicine 25(5): P120-21 (1984).
D. R. Vera et al., "Tc-99m-Galactosyl-Neoglycoalbumin: In Vivo Characterization of Receptor-Mediated Binding to Hepatocytes", Radiology 151(1): 191-196 (1984).
D. A. Goodwin et al., "Chelate Conjugates of Monoclonal Antibodies for Imaging Lymphoid Structures in the Mouse", The Journal of Nuclear Medicine 26(5): 493-502 (1985).

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