Chemistry of inorganic compounds – Treating mixture to obtain metal containing compound – Radioactive metal
Patent
1985-01-30
1987-05-05
Terapane, John F.
Chemistry of inorganic compounds
Treating mixture to obtain metal containing compound
Radioactive metal
250432PD, 252645, G21G 408, C01G 2900, C22B 1300, A61K 4300
Patent
active
046631291
ABSTRACT:
A method and apparatus for providing radionuclides of bismuth-212 and lead-212. Thorium-228 and carrier solution starting material is input to a radiologically contained portion of an isotopic generator system, and radium-224 is separated from thorium-228 which is retained by a strongly basic anion exchange column. The separated radium-224 is transferred to an accessible, strongly acidic cationic exchange column. The cationic column retains the radium-224, and natural radioactive decay generates bismuth-212 and lead-212. The cationic exchange column can also be separated from the contained portion of the system and utilized without the extraordinary safety measures necessary in the contained portion. Furthermore, the cationic exchange column provides over a relatively long time period the short lived lead-212 and bismuth-212 radionuclides which are useful for a variety of medical therapies.
REFERENCES:
patent: 2873170 (1959-02-01), Hyde et al.
patent: 4206358 (1980-06-01), Matthews et al.
Int. J. Nucl. Med. Biol., vol. 9, #1, p. 83, G. L. Zucchini et al., 1982.
Rosenow et al., "International Journal of Nuclear Medicine and Biology", vol. 10, pp. 189-197 (1983).
Buchanan et al., "International Atomic Energy Agency Conference at Copenhagen", vol. II, pp. 361-371 (1962).
Gansow et al., "ACS Symposium Series No. 241", pp. 216-227 (1984).
Atcher Robert W.
Friedman Arnold M.
Hines John
Caress Virginia B.
Churm Arthur A.
Hightower Judson R.
Terapane John F.
The United States of America as represented by the United States
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