Isotonic fat emulsion containing omega-3-fatty acids and use the

Details Isotonic fat emulsion containing omega-3-fatty acids and use the Isotonic fat emulsion containing omega-3-fatty acids and use the

1994-09-06

1999-02-23

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514458, 514549, 514552, A61K 3122, A61K 31355, A61K 3123

Patent

active

058744703

ABSTRACT:
Isotonic fat emulsions are provided which incorporate .omega.-3-fatty acids, .omega.-6-fatty acids, and medium-chain triglycerides. The emulsions are useful for parenteral application in post-aggression metabolism, in cases of chronic inflammatory diseases, and in neonatology and pediatrics. Due to the combination of .omega.-3-fatty acids and/or their physiologically acceptable esters with medium-chain-triglycerides, the medium-chain triglycerides are preferred to be oxidized in the organism, and the .omega.-3 fatty acids are protected from rapid oxidation, so that they are available to a higher extent for the formation of triply unsaturated eicosanoids. Furthermore, a liver protective effect is attained by the combination.

REFERENCES:
patent: 4526902 (1985-07-01), Rubin
patent: 4703062 (1987-10-01), Blackburn et al.
patent: 4871768 (1989-10-01), Bistrian et al.
patent: 4920098 (1990-04-01), Cotter et al.
patent: 5034414 (1991-07-01), Wakabayashi et al.
patent: 5574065 (1996-11-01), Trimbo
Marra et al., "Dexamethasone Blocks Arachidonate Biosynthesis in Isolated Hepatocytes and Cultured Hepatoma Cells" lipids, 21:212-219 (1986).
Gomez Dumm et al., "Effect of epinephrine on the oxidative desaturation of fatty acids in the rat" J. Lipid Res., 17:616-621 (1976).
Gomez Dumm et al., "Effect of Catecholamines and .beta.-Blockers on Linoleic Acid Desaturation Activity" Lipids, 13:649-652 (1978).
Gomez Dumm et al., "Effect of glucocorticoids on the oxidative desaturation of fatty acids by rat liver microsomes" J. Lipid Res., 20:834-839 (1979).
Mercuri et al., Biochim. Biophys. Acta, 116:409-411 (1966).
Hansen et al., "Influence of Diet on Blood Serum Lipids in Pregnant Women and Newborn Infants" American Jounral of Clinical Nutrition, 15:11-19 (1964).
Mendy et al., "Etude de la Composition en acides Gras Polydesatures des Lipides Seriques de Nourrissons Soumis a des Regimes Differents" Ann. Nutr. Alim., 22:267-285 (1968).
Mendy et al., "Facts About Linoleic Acid Metabloic Fate During Pufa Rich Diets in Human" Lipid metabolism and its pathology, M.J. Halpern, editor, 213-223 (1986).
Blond et al., "Desaturation comparee des acides linoleique et dihomo-.gamma.-linolenique par des homogenats de foie humain in vitro" C.R. Acad. Sc. Paris, 292:911-914 (1981).
Rivers et al., "Inability of the cat to desaturate essential fatty acids" Nature, 258:171-173 (1975).
Iacono et al., "Change in Plasma and Erythrocyte Lipids During Short-Term Administration of Intravenous Fat Emulsion and Its Subfractions" American Journal of Clinical Nutrition, 16:165-172 (1965).
Breton et al., "Interet des Acides Gras Polydesatures Essentials Dans la Pratique Quotidinne de la Medecine D'Enfants" La Revue de Pediatrie, 1:43-55 (1966).
Nouvelot et al., "Etude metabolique de trois emulsions lipidiques utiliseees dans l'alimentation parenterale" Nutr. Metabol. 19:307-317 (1975).
Agradi et al., "Influence of Short Term Dietary Supplementaion O Different Lipids on Aggregation and Arachidonic Acid Metabolism in Rabbit Platelets" Prostaglandins, 16:973-984 (1978).
Galli et al., "Differential Effects of Dietary Fatty Acids on the Accumlation of Arachidonic Acid and Its Metabolic Coinversion through the Cyclooxygenase and Lipoxygenase in Platelets and Vascular Tissue" Lipids, 16:165-172 (1981).
Friedman et al., "Essential Fatty Acids and the Major Urinary Metabolites of the E Prostaglandins in Thriving Neonates and in Infants Receiving Parenteral Fat Emulsions" Pediat. Res., 13:932-936 (1979).

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