Isothiourea synthesis process

Details Isothiourea synthesis process Isothiourea synthesis process

1984-11-29

1986-05-06

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27730

Patent

active

045873445

ABSTRACT:
N-methyl-S-methyl-N'-[2-(2-dimethylaminomethylthiazol-4-ylmethylthio)ethyl] isothiourea is prepared by the reaction of 2-dimethylaminomethyl-4-(2-aminoethyl)thiomethylthiazole with methylcarbonimidodithioic acid, dimethyl ester, and is a useful intermediate for the preparation of nizatidine, a pharmaceutically valuable H.sub.2 -receptor inhibitor.

REFERENCES:
patent: 4285952 (1981-08-01), Durant
patent: 4375547 (1983-03-01), Pioch

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