Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-04-17
1980-03-04
Raymond, Richard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
548214, 548127, 548206, 548255, 548128, 548263, 548265, 548129, 548266, 548130, 548269, 548262, 548134, 548183, 548184, 548135, 548186, 548191, 548136, 548205, 548138, 548243, 548244, 424269, 424270, 424272, 546264, 546275, 546276, 546280, 546331, 546261, 546277, 546291, 546305, 548245, 548246, 548247, 548249, 548240, 548213, A61K 31425, A61K 3144, C07D21359, C07D27730
Patent
active
041917693
ABSTRACT:
The compounds are N-(heterocyclomethylthioalkyl) derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'(heterocyclomethylthioalkyl) substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
REFERENCES:
patent: 3734924 (1973-05-01), Black et al.
patent: 3736331 (1973-05-01), Black et al.
patent: 4025527 (1977-05-01), Durant et al.
Derwent Abstract No. 19437v of Belgium Pat. No. 804,144, (patent published 2-1974).
Derwent Abstract No. 19438v of Belgium Pat. No. 804,145, (patent published 2-1974).
Derwent Abstract No. 03751w of Belgium Pat. No. 816,850, (patent published 12-1974).
Durant Graham J.
Ganellin Charon R.
Young Rodney C.
Edgerton William H.
Foggio Richard D.
Keps Joan S.
Raymond Richard
Smith Kline & French Laboratories Limited
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