Isothiocyanato-azobenzene-sulfonic, arsonic and substituted-glut

Details Isothiocyanato-azobenzene-sulfonic, arsonic and substituted-glut Isothiocyanato-azobenzene-sulfonic, arsonic and substituted-glut

1981-11-27

1984-04-10

Higel, Floyd D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260148, 260174, 260178, 260184, 260186, 260187, 260206, 260207, 260141, C07C10706, C07C11304, C09B 2912, C09B 33044

Patent

active

044420323

ABSTRACT:
Compounds of formula (I) ##STR1## in which n is 1 or 2, R.sup.1 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, amino, halo or hydroxy, m is 0, 1 or 2, R.sup.2 is an immunogenic determinant and x is 1 or 2, provided that when n is 1, x is 1 or 2 and there is one diazo moiety at the 3-position or two diazo moieties at the 3- and 5-positions, with respect to the isothiocyanate group, and the hydroxy group is at the 4-position; and provided that when n is 2, x is 1 and the diazo moiety is at the 4-position and the hydroxy groups are at the 3- and 5-positions, are described. The compounds are useful in the preparation of immunoglobulin conjugates for employment in diagnostic techniques.

REFERENCES:
patent: 2993886 (1961-07-01), Weis et al.
patent: 4118383 (1978-10-01), Botros
Wofsy & Henry, Contemporary Topics in Molecular Immunology, 7, 215 (1978), Plenim Press.
Cammisuli & Wofsy, J. Immun., 117, 1695 (1976).

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