Isothiocyanated cyclodextrin derivative

Details Isothiocyanated cyclodextrin derivative Isothiocyanated cyclodextrin derivative

1996-07-05

1998-08-04

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536103, C08B 3018

Patent

active

057895694

ABSTRACT:
The present invention relates to an isothiocyanated cyclodextrin derivative which can label various kinds of organic compounds containing an amino group as their functional group. In some embodiments, the derivative can be a cyclodextrin derivative in which at least one primary hydroxyl group is substituted by an isothiocyanato group and expressed by the compound expressed by formula (I), ##STR1## wherein n is an integer from 5 to 7.

REFERENCES:
Wang et al., "Photoreactive .sup.111 In-Cyclodextrin Inclusion Complex: a New Heterobifunctional Reagent for Antibody Labeling", Nucl. Med. Biol., vol. 19, No. 8, 1992, pp. 897-902.
Brown et al., "Synthesis and Properties of 6.sup.A -Amino-6.sup.A -deoxy-.alpha.-and -.beta.-cyclodextrin", Aust. J. Chem., vol. 46, 1993, pp. 953-958.
Melton et al., "Synthesis of Monosubstituted Cyclohexaamyloses", Carbohydrate Research, vol. 18, 1971, pp. 29-37.
Smith et al., "Photochemistry of 6-Propyl-2-cyclohexenone", Journal of Organic Chemistry, vol. 37, No. 8, Apr. 21, 1972, pp. 1259-1262.
Marvel et al., "n-Dodecyl (Lauryl) .rho.-Toluenesulfonate", Organic Syntheses, vol. 20, 1940, pp. 50-51.
Ackerman et al., "A New Synthesis of 5-Phenyl-2,3-dihydro-and 2,3,4,5-Tetrahydro-1H-2-benzazepin-1-ones", Canadian Journal of Chemistry, vol. 50, No. 23, Dec. 1, 1972, pp. 3886-3891.

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