Isothiazolyl substituted glycerol derivatives containing phospha

Details Isothiazolyl substituted glycerol derivatives containing phospha Isothiazolyl substituted glycerol derivatives containing phospha

1989-06-16

1991-11-26

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 21, C07F 909, C07F 96561

Patent

active

050683403

ABSTRACT:
Glycerol derivatives having at least one heterocyclic group on the 1 or 2 position are PAF antagonists which may be used to treat asthma, inflammation and shock.

REFERENCES:
patent: 4408052 (1983-10-01), Hozumi et al.
patent: 4794183 (1988-12-01), Nakamura et al.
patent: 4891363 (1990-01-01), Nakamura et al.
patent: 4921865 (1990-05-01), Broquet et al.
N. Nakamura et al., "2-O-(3-Isoxazolyl) Glycerol Derivatives as PAF Agonists and Antagonists"; Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, May 8-12, 1989, Tokyo, Japan, p. 96.
Upjohn, Abstract U-66985, J. Biol. Chem., 260,12710-12714 (1985).
Research Communications in Chemical Pathology and Pharmacology, 38, 3 et seq. (1982).
Nakamura et al., Tetrahedron Letters, 31, 699-702 (1990).

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