Isothiazolones lower plasma levels of lipoprotein(a)

Details Isothiazolones lower plasma levels of lipoprotein(a) Isothiazolones lower plasma levels of lipoprotein(a)

1996-05-07

1997-09-16

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514258, 514301, A61K 3141

Patent

active

056681623

ABSTRACT:
Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het.

REFERENCES:
patent: 3012039 (1961-12-01), Morley et al.
patent: 3517022 (1970-06-01), Miller et al.
patent: 3661974 (1972-05-01), Grivas
patent: 3761489 (1973-09-01), Grivas
patent: 3965107 (1976-06-01), Rainey et al.
patent: 4049817 (1977-09-01), Laber et al.
patent: 4093730 (1978-06-01), Butti et al.
patent: 4156729 (1979-05-01), Boshagen et al.
patent: 4458942 (1984-07-01), Shroot et al.
patent: 4512985 (1985-04-01), Maignan et al.
patent: 5153212 (1992-10-01), Shroot et al.
patent: 5219875 (1993-06-01), Sherba et al.
Okachi, et al., J. Med. Chem., vol. 28, No. 12, pp. 1772-1779 (1985).
Carmellino, et al., Eur. J. Med. Chem., vol. 29, pp. 743-751 (1994).
Schaper, Synthesis, pp. 861-867 (1985).
Auerbach, et al., Analytical Biochemistry, vol. 201, pp. 375-380 (1992).

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