Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-04-21
1995-11-14
Gerstl, Robert
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
A01N 4380
Patent
active
054668140
ABSTRACT:
Compounds of the general formula ##STR1## are cyclized to the corresponding isothiazolinone using a carbonyl halide of the formula RCOX where R is halogen or alkyl and X is halogen. R.sup.3 and R.sup.4 are preferably such as to form a 5 or 6 membered ring. Useful carbonyl halides are phosgene and propionyl chloride. Using acyl halides such as propionyl chloride, a mixture of the isothiazolinone and a salt of the carboxylic acid can be obtained, for example an essentially equimolar mixture of 2-methyl-4,5-trimethyl-4-isothiazolin-3-one and sodium propionate.
REFERENCES:
patent: 4568781 (1986-02-01), Effenberger et al.
patent: 4751311 (1988-06-01), Beckhouse
patent: 4851541 (1989-07-01), Maignan et al.
patent: 5049677 (1991-09-01), Prout et al.
Moffatt Frank S.
Winstanley David
Gerstl Robert
Zeneca Limited
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