Isothiazole derivatives useful as anticancer agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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C544S405000, C546S271100, C548S213000

Reexamination Certificate

active

10626406

ABSTRACT:
The invention relates to compounds of the formula 1or pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof, wherein wherein X, R1, and R2are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

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Edsjo, Anders, et al., Differences n Early and Late Responses between Neurotrophin-stimulated trkA- trkC-transafected SH-5Y5Y Neuroblastoma Cells, Cell Growth & Differentiation, vol. 12, pp. 39-50 (Jan. 2001).

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