Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-04-18
2006-04-18
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S353000, C544S354000, C544S355000, C544S356000
Reexamination Certificate
active
07030125
ABSTRACT:
Novel isothiazole and isoxazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
REFERENCES:
patent: 1251126 (2002-10-01), None
patent: 50 095272 (1975-07-01), None
patent: WO 9852937 (1998-11-01), None
patent: WO 9852941 (1998-11-01), None
patent: WO 0031063 (2000-06-01), None
patent: WO 0061576 (2000-10-01), None
patent: WO 0162756 (2001-08-01), None
patent: WO 0172737 (2001-10-01), None
patent: WO 0216359 (2002-02-01), None
patent: WO 0240468 (2002-05-01), None
patent: WO 0240476 (2002-05-01), None
patent: WO 0255077 (2002-07-01), None
patent: WO 0262776 (2002-08-01), None
patent: WO 0262787 (2002-08-01), None
patent: WO 0262794 (2002-08-01), None
patent: WO 0266462 (2002-08-01), None
patent: WO 0387304 (2003-10-01), None
patent: WO 0413135 (2004-02-01), None
J. Singh, et al., “Successful Shape-Based Virtual Screening: The Discovery of a Potent Inhibitor of the Type I TGFβ Receptor Kinase (TβRI)”,Bioorganic&Medicinal Chemistry Letters, 13 (2003) 4355-4359.
Blumberg Laura C.
Munchhof Michael J.
Morris Patricia L.
Pfizer Inc.
Sisti Nicholas J.
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