Isosteric peptides

Details Isosteric peptides Isosteric peptides

1994-08-10

1995-06-13

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514822, 530331, A61K 3702, C07K 508

Patent

active

054242916

ABSTRACT:
Compounds of formula I relate to the peptide sequence of human fibrogen A.alpha. chain, with modified positions 14 through 17 (P.sub.3 -P.sub.1.sup.1), which may be a useful inhibitor of thrombin. The antithrombin and anticoagulant compounds of this invention, therefore, have therapeutic potential in treatment or prophylaxis of thrombosis and related atherosclerotic diseases. A procedure for the synthesis of peptides according to formula I is also described.

REFERENCES:
patent: 4318904 (1982-03-01), Shaw et al.
Yang et al. Biochem J. 272(2), 399-406 (1990).

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