Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-10-10
1999-01-19
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242691, 435 693, 435947, 530324, 530350, 530806, 530822, 930210, A61K 39002, C12P 2102, C07K 1444
Patent
active
058611606
ABSTRACT:
Isospora suis is propagated using a swine testicular cell line which facilitates production of sporozoites and merozoites, either or both of which can be used in a vaccine for swine. Antibodies against Isospora suis sporozoites, which inhibit the infectivity of the sporozoites for the swine testicular cells, were made. These neutralizing antibodies were used to identify an apparent sporozoite attachment protein and cloned cDNA encoding a portion of the protein. The cloned cDNA was sequenced and the corresponding amino acid sequence of the antigenic sporozoite protein revealed two areas having repeated amino acid sequences, which may likewise be used in a vaccine.
REFERENCES:
patent: 4438097 (1984-03-01), Shirley
patent: 4639372 (1987-01-01), Murray et al.
patent: 4650676 (1987-03-01), Schenkel et al.
patent: 4724145 (1988-02-01), Murray et al.
patent: 4874705 (1989-10-01), Andrews et al.
patent: 5122471 (1992-06-01), Jenkins et al.
patent: 5273901 (1993-12-01), Jacobson et al.
patent: 5279960 (1994-01-01), Anderson et al.
Lewin, 1987. Science 237:1570.
Gmachl et al., 1990. Dermal Glands of Xenopus laevis. . . FEBS Lett. 260:145-8. Swiss-Prot 31 Database entry, #P17434;Q089440.
Maurer et al., 1980. Proteins and Polypeptides as Antigens. Meth Enzymol. 70:49-70.
American Journal Of Veterinary Research, vol. 52, No. 3, Mar. 1991, pp. 471-473, XP000601601 D.S. Lindsay Et Al.: "Ultrastructure of developing Isospora suis in cultured cells".
Doran, Eimeria tenella: From Sporozoites to Oocysts in Cell Culture, Proceedings of the Helminthological Society of Wash., vol. 37, No. 1, pp. 84-92, Jan. 1970.
Fayer, et al., Isospora suis: Development in Cultured Cells with Some Cytological Observations, Proc. Helminthol. Soc. Wash., vol. 51, No. 1, pp. 154-159, 1984.
Laurent, et al., The immunodominant Eimeria acervulina sporozoite antigen previously described as p160/p240 is a 19-kilodalton antigen present in several Eimeria species, Mol. Biochem. Para., vol. 63, pp. 79-86, 1994.
Lindsay, et al., Complete Development of Isospora suis of Swine in Chicken Embryos, J. Protozool., vol. 31, No. 1, pp. 152-155, 1984.
Lindsay, et al., Biology of Mammalian Isospora, Parasitology Today, vol. 10, No. 6, pp. 214-220, 1994.
Lindsay, et al., Development of Isospora suis from Pigs in Primary Porcine and Bovine Cell Cultures, Veterinary Parasitology, vol. 24, pp. 301-304, 1987.
Reduker, et al., Proteins and Antigens of Merozoites and Sporozoites of Eimeria Bovis (Apicomplexa), J. Parasit., vol. 72, No. 6, pp. 901-907, 1986.
Quick Douglas P.
Steger Ann M.
Welter C. Joseph
Welter Lisa M.
Welter Mark W.
Ambico Inc.
Blackstone William M.
Grun James L.
Housel James C.
LandOfFree
Isospora suis sporozoite antigen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isospora suis sporozoite antigen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isospora suis sporozoite antigen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1245016