Isoquinolyl substituted hydroxylamine derivatives

Details Isoquinolyl substituted hydroxylamine derivatives Isoquinolyl substituted hydroxylamine derivatives

1992-06-03

1993-11-09

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514213, 5142265, 514372, 514416, 540523, 540552, 544 49, 546141, 546142, 546144, 546146, 546147, 546148, 546149, 546150, 546151, 548207, 548472, A61K 3147, C07D21706, C07D21716

Patent

active

052603164

ABSTRACT:
The compounds of the formula ##STR1## wherein R represents hydrogen, lower alkyl, aryl, biaryl, C.sub.3 -C.sub.7 -cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl, aryloxy-lower alkyl, arylthio-lower alkyl; C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, biaryl-lower alkyl, aryl-C.sub.3 -C.sub.7 -cycloalkyl, aryl-C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl or aryloxy-aryl-lower alkyl; and aryl represents carbocyclic or heterocyclic aryl; Z represents C.sub.1 -C.sub.3 -alkylene or vinylene, each unsubstituted or substituted by lower alkyl; Y represents SO.sub.2 or CO; A represents O, S, or a direct bond; B represents lower alkylene; or B represents lower alkenylene provided that A represents a direct bond; X represents oxygen or sulfur; R.sub.1 represents hydrogen, acyl, lower alkoxycarbonyl, aminocarbonyl, mono or di-lower alkylaminocarbonyl, lower alkenylaminocarbonyl, lower alkynylaminocarbonyl, carbocyclic or heterocyclic aryl-lower alkylaminocarbonyl, carbocyclic or heterocyclic arylaminocarbonyl, C.sub.3 -C.sub.7 -cycloalkylaminocarbonyl or C.sub.3 -C.sub.7 -cycloalkyl-lower alkylaminocarbonyl; R.sub.2 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C.sub.3 -C.sub.7 -cycloalkylamino, C.sub.3 -C.sub.7 -cycloalkyl-lower alkylamino or lower alkoxycarbonyl-lower alkylamino; R.sub.3 and R.sub.4 independently represent hydrogen or lower alkyl; R.sub.a represents hydrogen, lower alkyl, halo, trifluoromethyl or lower alkoxy; and pharmaceutically acceptable salts thereof; their preparation and use as lipoxygenase inhibitors are described.

REFERENCES:
patent: 4738986 (1988-04-01), Kneen et al.
patent: 4757078 (1988-07-01), Misra
patent: 4769461 (1988-09-01), Musser et al.
patent: 4792560 (1988-12-01), Huang
patent: 4873259 (1989-10-01), Summers, Jr. et al.
patent: 4981865 (1991-01-01), Belliotti et al.
patent: 5004747 (1991-04-01), Ashton et al.
patent: 5006534 (1991-04-01), Mohrs et al.
patent: 5036157 (1991-07-01), Kneen et al.
patent: 5084575 (1992-01-01), Kreft, III et al.
patent: 5162340 (1992-11-01), Chakravarty et al.
Molecular Pharmacology, vol. 40, p. 22 (1991).

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