Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-11-21
1992-05-19
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546141, 546157, 546158, 546172, 544237, 544239, 544287, 548221, 548472, 548506, 514416, 514247, 514248, 514259, 514312, 514376, 514418, A61K 3140, A61K 3147, C07D20946, C07D21722
Patent
active
051149524
ABSTRACT:
A series of novel alkanesulphonamidophenyl-N-alkyl-N-(heterocyclic-alkyl)alkylamine derivatives have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in therapy as anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. Said sulfonamide compounds are of the formula: ##STR1## wherein R and R.sup.1 are each C.sub.1 -C.sub.4 alkyl; X is --CH.sub.2 --, --CO-- or --CH(OH)--; n is two, three or four; and "Het" is a nitrogen-containing heterocyclic group wherein said heterocyclic group is preferably 2H-3,4-dihydroisoquinol-1-on-2-yl or 2H-isoquinol-1-on-2-yl, each optionally substituted with halogen or C.sub.1 -C.sub.4 alkyl.
REFERENCES:
patent: 4137318 (1979-01-01), Eberlein et al.
patent: 4460581 (1984-07-01), Schromm et al.
Arrowsmith John E.
Cross Peter E.
Thomas Geoffrey N.
Ginsburg Paul H.
Grumbling Matthew V.
Pfizer Inc.
Richardson Peter C.
Shah Mukund J.
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