Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-08-25
1995-03-21
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D21702
Patent
active
053996968
ABSTRACT:
This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.
REFERENCES:
patent: 4902695 (1990-02-01), Ornstein
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Buchan et al., "Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia", Neuroreport, 2, 473-476 (1991).
LePeillet et al., "The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rate", Brain Research, 571, 115-120 (1992).
Ornstein et al., "Synthesis of 6-Oxodecahydroisoquinoline-3-carboxylates. Useful Intermediates for the Preparation of Conformationally Defined Excitatory Amino Acid Antagonists", J. Org. Chem., 56, 4388-4392 (1991).
Jacques et al., Enantiomers, Racemates, and Resolutions, 253-259, John Wiley and Sons, N.Y., (1981).
Arnold M. Brian
Augenstein Nancy K.
Lunn William H. W.
Ornstein Paul L.
Davis Zinna N.
Eli Lilly and Company
Ivy C. Warren
Leeds James P.
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