Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-01
1997-02-25
Davis, Zinna Northington
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D21716
Patent
active
056060629
ABSTRACT:
This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.
REFERENCES:
patent: 4902695 (1990-02-01), Ornstein
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Buchan et al., "Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia", Neuroreport, 2, 473-476 (1991).
LePeillet et al., "The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat", Brain Research, 571, 115-120 (1992).
Ornstein et al., "Synthesis of 6-Oxodecahydroisoquinoline-3-carboxylates. Useful Intermediates for the Preparation of Conformationally Defined Excitatory Amino Acid Antagonists", J. Org. Chem., 56, 4388-4392 (1991).
Jacques et al., Enantiomers, Racemates, and Resolutions, 253-259, John Wiley and Sons, N.Y., (1981).
Ornstein et al., "6-Substituted Decahydroisoquinoline-3-carboxylic Acids as Potent and Selective Conformationally Constrained NMDA Receptor Antagonists", J. Med. Chem., 35, 3547-3560 (1992).
Davis Zinna Northington
Eli Lilly and Company
Hay Martin A.
Leeds James P.
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