Isoquinolinyl-carboxylic acid receptor antagonists compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D21716

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active

056060629

ABSTRACT:
This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.

REFERENCES:
patent: 4902695 (1990-02-01), Ornstein
Sheardown et al., "2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxalfine: A Neuroprotectant for Cerebral Ischemia", Science, 247, 571-574 (1990).
Buchan et al., "Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia", Neuroreport, 2, 473-476 (1991).
LePeillet et al., "The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat", Brain Research, 571, 115-120 (1992).
Ornstein et al., "Synthesis of 6-Oxodecahydroisoquinoline-3-carboxylates. Useful Intermediates for the Preparation of Conformationally Defined Excitatory Amino Acid Antagonists", J. Org. Chem., 56, 4388-4392 (1991).
Jacques et al., Enantiomers, Racemates, and Resolutions, 253-259, John Wiley and Sons, N.Y., (1981).
Ornstein et al., "6-Substituted Decahydroisoquinoline-3-carboxylic Acids as Potent and Selective Conformationally Constrained NMDA Receptor Antagonists", J. Med. Chem., 35, 3547-3560 (1992).

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