Isoquinolinium substituted cephalosporins

Details Isoquinolinium substituted cephalosporins Isoquinolinium substituted cephalosporins

1981-09-08

1983-05-10

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, 544 27, 544 28, 548133, 548233, 548245, A61K 31545, C07D50146

Patent

active

043829325

ABSTRACT:
Broad spectrum cephalosporin antibiotics represented by the formula ##STR1## wherein R is a 3-aminoisoxazol-5-yl, 2-aminooxazol-4-yl, or a 5-amino-1,2,4-oxadiazol-3-yl group; R.sub.1 is isoquinolinium or substituted isoquinolinium; and R' is C.sub.1 -C.sub.4 alkyl, an N-substituted carbamoyl group, or a carboxy-substituted alkyl or cycloalkyl group; and the pharmaceutically acceptable non-toxic salts thereof; are prepared by the reaction of a 3-iodomethyl cephalosporin, having the above 2-(amino-substituted heterocyclic)-2-oximinoacetyl side chain, with isoquinoline or a substituted isoquinoline. Pharmaceutical formulations of the antibiotics and a method for treating bacterial infections with the antibiotics are provided.

REFERENCES:
patent: 3960849 (1976-06-01), Breuer
patent: 4024133 (1977-05-01), Cook et al.
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
Derwent Abstract No. 32890.

Affiliated with

Also associated with

Rating

Isoquinolinium substituted cephalosporins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isoquinolinium substituted cephalosporins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isoquinolinium substituted cephalosporins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-525901