Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-06-13
1978-10-24
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
260287CE, 260288CE, A61K 3147, C07D40104
Patent
active
041221800
ABSTRACT:
Isoquinolines of the formula ##STR1## wherein R.sup.1 is H or alkyl of 1 - 4 carbon atoms, R.sup.2 is H and R.sup.3 is OH or R.sup.2 and R.sup.3 collectively are a C--C bond, and physiologically acceptable acid addition salts thereof have anti-depressant activity and can be prepared by solvolyzing or hydrogenolyzing a compound of the formula ##STR2## or an acid addition salt thereof, wherein R.sup.4 is R.sup.1 or R.sup.6, R.sup.5 is OR.sup.7 or, when R.sup.4 is R.sup.6, R.sup.3 ; R.sup.6 and R.sup.7 are radicals which can be split off solvolytically or hydrogenolytically and R.sup.1 and R.sup.2 are as above; and the optional step of dehydrating a resulting carbinol (R.sup.2 is H, R.sup.3 is OH) and/or treating a resulting compound (R.sup.1 is H) with a N-alkylating agent and/or converting a resulting base to a physiologically acceptable acid addition salt by treatment with and acid.
REFERENCES:
patent: 3479358 (1969-11-01), Hansen et al.
patent: 3901897 (1975-08-01), Hauck
patent: 4048177 (1977-09-01), Black
Berger et al., Chemical Abstracts, vol. 42, 3403i-3404f (1947).
Sugimoto et al., Chemical Abstracts, vol. 51, 16, 563i (1957).
Barrett et al., Chemical Abstracts, vol. 52, 11,845e (1958).
Nakananishi et al., Chemical Abstracts, vol. 79, 115,448a (1973).
Mueller-Calgan Helmut
Pohlke Rolf
Seyfried Christoph
Strehlow Wighard
Coughlan, Jr. Paul M.
Merck Patent Gesellschaft mit beschraenkter Haftung
Rivers Diana G.
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