Isoquinolines and anti-depressants containing them

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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260287CE, 260288CE, A61K 3147, C07D40104

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active

041221800

ABSTRACT:
Isoquinolines of the formula ##STR1## wherein R.sup.1 is H or alkyl of 1 - 4 carbon atoms, R.sup.2 is H and R.sup.3 is OH or R.sup.2 and R.sup.3 collectively are a C--C bond, and physiologically acceptable acid addition salts thereof have anti-depressant activity and can be prepared by solvolyzing or hydrogenolyzing a compound of the formula ##STR2## or an acid addition salt thereof, wherein R.sup.4 is R.sup.1 or R.sup.6, R.sup.5 is OR.sup.7 or, when R.sup.4 is R.sup.6, R.sup.3 ; R.sup.6 and R.sup.7 are radicals which can be split off solvolytically or hydrogenolytically and R.sup.1 and R.sup.2 are as above; and the optional step of dehydrating a resulting carbinol (R.sup.2 is H, R.sup.3 is OH) and/or treating a resulting compound (R.sup.1 is H) with a N-alkylating agent and/or converting a resulting base to a physiologically acceptable acid addition salt by treatment with and acid.

REFERENCES:
patent: 3479358 (1969-11-01), Hansen et al.
patent: 3901897 (1975-08-01), Hauck
patent: 4048177 (1977-09-01), Black
Berger et al., Chemical Abstracts, vol. 42, 3403i-3404f (1947).
Sugimoto et al., Chemical Abstracts, vol. 51, 16, 563i (1957).
Barrett et al., Chemical Abstracts, vol. 52, 11,845e (1958).
Nakananishi et al., Chemical Abstracts, vol. 79, 115,448a (1973).

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