Isoquinoline derivatives for the treatment of glaucoma or ocular

Details Isoquinoline derivatives for the treatment of glaucoma or ocular Isoquinoline derivatives for the treatment of glaucoma or ocular

1992-04-30

1993-10-12

Fay, Zohreh A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514913, A61K 3147

Patent

active

052525830

ABSTRACT:
The use of isoquinoline derivatives for the treatment of glaucoma or ocular hypertension. The isoquinoline derivatives are of formula I ##STR1## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group and R.sub.2 is a C.sub.1 -C.sub.6 alkyl group. The stability of the isoquinoline derivatives when used in the form of a solution is improved by incorporating therein compounds having a phenolic hydroxyl group and/or glycols serving as a stabilizer.

REFERENCES:
patent: 4517365 (1985-05-01), Koyama et al.
patent: 4659833 (1987-04-01), Takahashi et al.
Physician's Desk Reference for Ophthamology, 16 Edition, 1988, p. 11.

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